Publications & Conference Abstracts

Wearable and implantable artificial kidney devices for endstage kidney disease treatment—Current status and review

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Innovations in Wearable and Implantable ArtificialKidneys

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Current strategies and challenges in engineering a bioartificial kidney

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Selected Publications

  1. Kotzar G, Freas M, Abel P, Fleischman A, Roy S, Zorman C, Moran JM, Melzak J. Evaluation of MEMS materials of construction for implantable medical devices. Biomaterials 2002;23(13):2737-2750.
  2. Fissell WH, Manley S, Westover A, Humes HD, Fleischman AJ, Roy S. Differentiated growth of human renal tubule cells on thin-film and nanostructured materials. ASAIO J 2006;52(3):221-7.
  3. Fissell WH, Humes HD, Fleischman AJ, Roy S. Dialysis and nanotechnology: now, 10 years, or never? Blood Purif 2007;25(1):12-7.
  4. Fissell WH, Fleischman AJ, Humes HD, Roy S. Development of continuous implantable renal replacement: past and future. Transl Res 2007;150(6):327-36.
  5. Fissell WH, Manley S, Dubnisheva A, Glass J, Magistrelli J, Eldridge AN, Fleischman AJ, Zydney AL, Roy S. Ficoll is not a rigid sphere. Am J Physiol Renal Physiol 2007;293(4):F1209-13.
  6. Conlisk AT, Datta S, Fissell WH, Roy S. Biomolecular transport through hemofiltration membranes. Ann Biomed Eng 2009;37(4):722-36.
  7. Fissell WH, Dubnisheva A, Eldridge AN, Fleischman AJ, Zydney AL, Roy S. High-performance silicon nanopore hemofiltration membranes. Journal of Membrane Science 2009;326(1):58-63.
  8. S. Roy, A. Dubnisheva, A. Eldridge, A.J. Fleischman, K.G. Goldman, H.D.Humes, A.L. Zydney, and W.H. Fissell, "Silicon nanopore membrane technology for an implantable artificial kidney," Proceedings of the 15th International Conference on Solid-State Sensors, Actuators, and Microsystems - Transducer 2009, Denver, CO, USA, 2009
  9. Fissell WH, Roy S. The implantable artificial kidney. Semin Dial 2009;22(6):665-70.
  10. Fissell WH, Hofmann CL, Ferrell N, Schnell L, Dubnisheva A, Zydney AL, Yurchenco PD, Roy S. Solute Partitioning and Filtration by Extracellular Matrices. Am J Physiol Renal Physiol 2009;297(4):F1092-100.
  11. Groszek J, Li L, Ferrell N, Smith R, Zorman CA, Hofmann CL, et al. Molecular conformation and filtration properties of anionic Ficoll. Am J Physiol Renal Physiol. 2010; 299(4):F752-7.
  12. Ferrell N, Desai RR, Fleischman AJ, Roy S, Humes HD, Fissell WH. A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells. Biotechnol Bioeng. 2010.
  13. Ferrell N, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH. Basal lamina secreted by MDCK cells has size- and charge-selective properties. Am J Physiol Renal Physiol. 2011;300(1):F86-90.
  14. Roy S. Goldman K. Marchant R. Zydney A. Brown D. Fleischman A. Conlisk A. Desai T. Duffy S. Humes H. Fissell W. Implanted renal replacement for end-stage renal disease. Panminerva Medica. 53(3):155-66, 2011
  15. Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S. Hemocompatibility of silicon-based substrates for biomedical implant applications. Ann Biomed Eng. 2011;39(4):1296-305.
  16. Smith RA, Fleischman AJ, Fissell WH, Zorman CA, Roy S. A system to measure minute hydraulic permeability of nanometer scale devices in a non-destructive manner. Meas Sci Technol. 2011:22(4).
  17. Fissell W.H., Roy S., Davenport A., Achieving More Frequent and Longer Dialysis for the Majority: Wearable Dialysis and Implantable Artificial Kidney Devices. Kidney Int. 2013 Aug; 84(2): 256-64.
  18. H. Humes, D. Buffington, A. Westover, S. Roy, W. Fissell. The Bioartificial Kidney: Current Status and Future Promise. J Pediatr Nephrol. 2014;29(3),343–351.
  19. S. Kim, W.H. Fissell, D.H. Humes, S. Roy. Current Strategies and Challenges in Engineering a Bioartificial Kidney. Front Biosci (Elite Ed). 7:215-28. 2015 Jan 1; 7:215-28.
  20. S. Kim, J. Heller, Z. Iqbal, R. Kant, EJ. Kim, J. Durack, M. Saeed, L. Do, S. Hetts, M. Willson, P. Brakeman, WH. Fissell, S. Roy. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO Journal, 2016 Mar; 62(2):169-75.
  21. C. Kensinger, S. Karp, R. Kant, BW. Chui, K. Goldman, T. Yeager, ER. Gould, A. Buck, DC. Laneve, JJ. Groszek, S. Roy, WH. Fissell. First implantation of Silicon Nanopore Membrane Hemofilters. ASAIO Journal, 2016 Mar; 62(4):491-5.
  22. S. Kim, B. Feinberg, R. Kant, B. Chui, K. Goldman, J. Park, W. Moses, C. Blaha, Z. Iqbal, C. Chow, N. Wright, W.H. Fissell, A. Zydney, S. Roy. Diffusive Silicon Nanopore Membranes for Hemodialysis Applications. PLoS One, 2016 Jul.
  23. Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics. 2016 Nov; 10(6):064106.
  24. Buck AKW, Groszek JJ, Colvin DC, Keller SB, Kensinger C, Forbes R, Karp S, Williams P, Roy S, Fissell WH. Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo. ASAIO J. 2017 Aug 29.
  25. Ferrell N, Cheng J, Miao S, Roy S, Fissell WH. Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells. ASAIO J. 2017 Dec 11
  26. Buck AKW, Goebel SG, Goodin MS, Wright NJ, Groszek JJ, Moyer J, Singh S, Bluestein D, Fissell WH, Roy S. Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney. J Biomech. 2018 Mar 1; 69:26-33
  27. Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S. Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration. J Colloid Interface Sci. 2018 May1;517:176-181. doi: 10.1016/j.jcis.2017.12.056. Epub 2017 Dec 20.
  28. Salani M, Roy S, Fissell WH 4th. Innovations in Wearable and Implantable Artificial Kidneys. Am J Kidney Dis. 2018 Nov; 72(5):745-751. doi: 10.1053/j.ajkd.2018.06.005. Epub 2018 Aug 23.
  29. Iqbal Z, Kim S, Moyer J, Moses W, Abada E, Wright N, Kim EJ, Park J, Fissell WH, Vartanian S, Roy S. In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants. J Biomater Appl. 2019 Aug; 34(2):297-312.
  30. Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing. J Pharmacol Exp Ther. 2019 06; 369(3):523-530.
  31. Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH. Application of physiological shear stress to renal tubular epithelial cells. Methods Cell Biol. 2019; 153:43-67.
  32. Fissell WH, Roy S. Treating the kidneys - a new era in the United States (and beyond). Nat Rev Nephrol. 2019 12; 15(12):727-728.
  33. Wilson MH, Veach RA, Luo W, Welch RC, Roy S, Fissell WH. Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function. Cell Mol Bioeng. 2020 Feb; 13(1):17-26.
  34. Hojs N, Fissell WH, Roy S. Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment. Clin J Am Soc Nephrol. 2020 Jan 07; 15(1):152-159.
  35. Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell NJ, Evans RC, Gewin L, Harris RC, Zent R, Roy S, Fissell WH. Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture. Tissue Eng Part A. 2018 Nov 28. doi: 10.1089/ten.TEA.2018.0182

Conference Abstracts

This is a compilation of abstracts our team has produced for the annual American Society for Artificial Internal Organs (ASAIO) and the annual American Society of Nephrology (ASN) Kidney Week conferences.

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The Kidney Project is a national research project with a goal to create a small, surgically implanted, and free-standing bioartificial kidney to treat kidney failure. The device is not yet available to the public and is still under research.

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